Avicenna regarded the heart as the chief organ (Aza’ e Raeeza) responsible for maintaining life and vitality by regulating blood circulation and distributing Rooḥ (Vital Spirit) throughout the body. According to Avicenna, heart diseases arise due to imbalances in the four humors (Akhlat), particularly an excess of Safra (Yellow Bile), which leads to heat-related disorders like palpitations and hypertension, and Balgham (Phlegm), which contributes to weakness of the heart and blocked arteries.

Avicenna recommended dietary management (Ilaj bil Ghiza) with heart-nourishing foods like pomegranate, saffron, honey, and barley water, along with herbal medicines to strengthen the heart and enhance circulation.

Avicenna, in his renowned work Adviyah-e-Qalbiyah (Cardiac Medicines) mentioned many herbal and natural formulations used to strengthen the heart, regulate blood circulation, and maintain cardiovascular health. He classified these medicines based on their effects, such as Muqawwi e Qalb (Cardiotonic), Musakhkin Qalb (Calming the heart), Mufarreh Qalb (Heart-rejoicing), and Musaffī Dam (Blood Purifiers). Among the most notable cardiac medicines, he recommended many Khamira preparations and Arq and Majoon which are still widely used in Unani medicine.

Furthermore, Avicenna highlighted the role of emotions and mental health (Ilaj bil Nafsani) in heart diseases, recognizing that excessive anger, grief, or stress could impair cardiac function. His holistic approach combined physical, dietary, pharmacological, and psychological interventions, making his contributions to cardiology highly influential and relevant even in modern medicine.

He also emphasized regimenal therapies (Ilaj bil Tadbir) like Dalk (Massage), Riyaḍat (Exercise), and Hijamah (Cupping Therapy) to regulate blood flow and detoxify the body.

This holistic approach integrated dietary therapy, herbal medicine, regimenal therapies, and psychological healing, making a comprehensive system for maintaining heart health and treating cardiovascular diseases.

Commonly manageable heart conditions include hypertension (Zaqat ul Dam Qawi), cardiac weakness (Zu‘f e Qalb), Palpitation  (Kafkhan), and atherosclerosis (arterial blockage) by holistic approach.